Article
Metabolism and successful aging: Polymorphic variation of syndecan-4 (SDC4) gene associate with longevity and lipid profile in healthy elderly Italian subjects.
Mechanisms of ageing and development - 1 Sept 2015
Rose Giuseppina, Crocco Paolina, De Rango Francesco, Corsonello Andrea, Lattanzio Fabrizia, De Luca Maria, Passarino Giuseppe
Abstract excerpt
Evidences from model systems and humans have suggested that genetic alterations in cell-ECM interactions and matrix-mediated cellular signaling cascades impact different aspects of metabolism and thereby life span. In this frame, a genetic variant (rs1981429) in the SDC4 gene encoding for syndecan-4, a central mediator of cell adhesion, has been associated with body composition in children and coronary artery...
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