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Article

Removal of an atypical region from a staphylococcal cyclophilin affects its structure, function, stability, and shape.

International journal of biological macromolecules - 15 May 2020

Seal Soham, Chowdhury Nilkanta, Biswas Ria, Chakraborty Tushar, Sinha Debabrata, Bagchi Angshuman, Sau Subrata

Abstract excerpt

SaCyp, a cyclophilin having 197 amino acid residues, acts both as a protein-folding catalyst and a virulence factor in Staphylococcus aureus. Interestingly, a region, homologous to the SaCyp region carrying 121-148 amino acid residues, is present in many putative cyclophilins but absent in well-studied cyclophilins. To determine the exact roles of this unusual region in SaCyp and related proteins, we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31751734
DOI: 10.1016/j.ijbiomac.2019.10.175

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