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Article

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

21 Jan 2003

Abstract excerpt

Polypeptide deformylase (PDF) catalyzes the deformylation of polypeptide chains in bacteria. It is essential for bacterial cell viability and is a potential antibacterial drug target. Here, we report the crystal structures of polypeptide deformylase from four different species of bacteria: Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Comparison of these four...

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PMID: 12538898
DOI: 10.1110/ps.0229303

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