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Article

An Intracellular Peptidyl-Prolyl cis/trans Isomerase Is Required for Folding and Activity of the Staphylococcus aureus Secreted Virulence Factor Nuclease.

Journal of bacteriology - 1 Jan 2017

Wiemels Richard E, Cech Stephanie M, Meyer Nikki M, Burke Caleb A, Weiss Andy, Parks Anastacia R, Shaw Lindsey N, Carroll Ronan K

Abstract excerpt

Staphylococcus aureus is an important human pathogen that relies on a large repertoire of secreted and cell wall-associated proteins for pathogenesis. Consequently, the ability of the organism to cause disease is absolutely dependent on its ability to synthesize and successfully secrete these proteins. In this study, we investigate the role of peptidyl-prolyl cis/trans isomerases (PPIases) on the activity of the...

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Identifiers

PMID: 27795319
DOI: 10.1128/JB.00453-16
PMCID: PMC5165095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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