Article
Serum response factor-dependent MicroRNAs regulate gastrointestinal smooth muscle cell phenotypes.
Gastroenterology - 1 Jul 2011
Park Chanjae, Hennig Grant W, Sanders Kenton M, Cho Jonathan H, Hatton William J, Redelman Doug, Park Jong Kun, Ward Sean M, Miano Joseph M, Yan Wei, Ro Seungil
Abstract excerpt
BACKGROUND & AIMS: Smooth muscle cells (SMCs) change phenotypes under various pathophysiological conditions. These changes are largely controlled by the serum response factor (SRF), a transcription factor that binds to CC (A/T)6 GG (CArG) boxes in SM contractile genes. MicroRNAs (miRNA) regulate transitions among SMC phenotypes. The SMC miRNA transcriptome (SMC miRNAome) and its regulation by SRF have not been...
Topics
- Animals
- Binding Sites
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Computational Biology
- Enhancer Elements, Genetic
- Gastrointestinal Tract
- Gene Expression Profiling
- Gene Expression Regulation