Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study.

doi:10.1093/jnci/dju252

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Article

Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study.

Journal of the National Cancer Institute - 1 Nov 2014

Thrift Aaron P, Shaheen Nicholas J, Gammon Marilie D, Bernstein Leslie, Reid Brian J, Onstad Lynn, Risch Harvey A, Liu Geoffrey, Bird Nigel C, Wu Anna H, Corley Douglas A, Romero Yvonne, Chanock Stephen J, Chow Wong-Ho, Casson Alan G, Levine David M, Zhang Rui, Ek Weronica E, MacGregor Stuart, Ye Weimin, Hardie Laura J, Vaughan Thomas L, Whiteman David C

Abstract excerpt

BACKGROUND: Data from observational studies suggest that body mass index (BMI) is causally related to esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE). However, the relationships may be affected by bias and confounding. METHODS: We used data from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study: 999 patients with EAC, 2061 patients with BE, and 2169 population...

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Identifiers

PMID: 25269698
DOI: 10.1093/jnci/dju252
PMCID: PMC4200028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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