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Article

Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis

19 Nov 2019

Abstract excerpt

OBJECTIVE: Familial adenomatous polyposis (FAP) is characterised by the development of hundreds to thousands of adenomas at different evolutionary stages in the colon and rectum that will inevitably progress to adenocarcinomas if left untreated. Here, we investigated the genetic alterations and transcriptomic transitions from precancerous adenoma to carcinoma. DESIGN: -associated polyposis (n=56 exomes, n=56...

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PMID: 31744909
DOI: 10.1136/gutjnl-2019-319438

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