Article

Multi-omic Analysis of Familial Adenomatous Polyposis Reveals Molecular Pathways and Polyclonal Spreading Associated with Early Tumorigenesis

2021-05-19

Abstract excerpt

<title>Abstract</title> <p>Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected patients, leading to colorectal cancer (CRC), and is an ideal model to study early transition to CRC. We performed deep multi-omic profiling of 135 normal mucosal, benign and dysplastic polyps and adenocarcinoma samples from 6 FAP patients who consented to broad data sharing. Wh...

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Literature Corpus work: 4d507148-55b7-53a7-bcd3-667613f9df57
DOI: 10.21203/rs.3.rs-515393/v1

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