Article

Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson’s Disease

2025-04-20

Abstract excerpt

<h4>Background and objective</h4> The discovery of cell-free micro-RNAs in body fluids has made them a promising biomarker target in the field of neurodegenerative diseases. Although they have been reported to be differentially expressed in biofluids and tissues from sporadic Parkinson’s disease patients, it remains unclear whether similar observations can be made in patients with genetic forms of the disease and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2b7a9a7-e39f-5ef0-97c8-c5d6286fa349
DOI: 10.1101/2025.04.15.648997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson’s DiseaseDOI 10.1101/2025.04.15.648997Read

The Cellular and Extra-Cellular Proteomic Signature of Human Dopaminergic Neurons Carrying the LRRK2 G2019S MutationSemantic proximity Read

Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.Semantic proximity Read

Identification of blood serum micro‐RNAs associated with idiopathic and LRRK2 Parkinson's diseaseSemantic proximity Read

Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson’s DiseaseSemantic proximity Read

Mitochondrial Dysfunction in Dopaminergic Neurons Derived from Patients with LRRK2- and SNCA-Associated Genetic Forms of Parkinson’s DiseaseSemantic proximity Read

Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's diseaseSemantic proximity Read

Parkinson’s Disease: From Genetics and Epigenetics to Treatment, a miRNA-Based StrategySemantic proximity Read

Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson’s Disease PatientsSemantic proximity Read

Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patientsSemantic proximity Read

Using Extracellular miRNA Signatures to Identify Patients with LRRK2-Related Parkinson's Disease.Semantic proximity Read

An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron diseaseSemantic proximity Read

Parkinson’s disease is associated with an imbalance in circular RNA expressionSemantic proximity Read