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Article

Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathway

15 Nov 2019

Abstract excerpt

Costunolide, an active sesquiterpene lactone, is derived from a number of medicinal plants and it exhibits a broad spectrum of bioactivities such as anti-inflammatory and potential anti-tumor activity. However, its effects on human osteosarcoma and the underlying mechanisms have not yet been evaluated. Here, we found Costunolide inhibits STAT3 transcriptional activity and the expression level of phospho-STAT3...

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PMID: 31739161
DOI: 10.1016/j.biopha.2019.109659

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