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Article

Osteosarcoma exocytosis of soluble LGALS3BP mediates macrophages toward a tumoricidal phenotype.

Cancer letters - 1 Mar 2022

Li Jing, Zhao Chenguang, Li Yuhuan, Wen Junxiang, Wang Shuang, Wang Difan, Dong Hui, Wang Dong, Zhao Yonglin, Wang Xiaohui, He Xijing, Qin Jie

Abstract excerpt

This study aimed to elucidate the interactions between osteosarcoma (OS) and M1 macrophages infiltrated into the tumor microenvironment and to explore the underlying mechanisms whereby M1 macrophages influence the growth of OS, so that novel treatments of OS can be developed. A transwell co-culture system, an indirect conditioned medium culture system and two orthotopic bearing OS models were established to...

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Identifiers

PMID: 34952143
DOI: 10.1016/j.canlet.2021.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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