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Article

Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein.

Mutation research - 1 Jan 2000

Curren R D, Yang L L, Conklin P M, Grafstrom R C, Harris C C

Abstract excerpt

Acrolein, a short-chain aldehyde encountered as a component of tobacco smoke and as a ubiquitous environmental contaminant, was tested for its toxic and mutagenic effects toward human fibroblast cells. We found that human cells characterized by a deficiency in DNA repair (cells from xeroderma pigmentosum (XP) patients) were much more sensitive (D37 approximately equal to 0.25 microM) to the cytotoxic effects of...

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Identifiers

PMID: 3173398
DOI: 10.1016/0165-7992(88)90104-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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