Article
Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein.
Mutation research - 1 Jan 2000
Curren R D, Yang L L, Conklin P M, Grafstrom R C, Harris C C
Abstract excerpt
Acrolein, a short-chain aldehyde encountered as a component of tobacco smoke and as a ubiquitous environmental contaminant, was tested for its toxic and mutagenic effects toward human fibroblast cells. We found that human cells characterized by a deficiency in DNA repair (cells from xeroderma pig...
Topics
- Acrolein
- Aldehydes
- Cell Line
- DNA Repair
- Dose-Response Relationship, Drug
- Humans
- In Vitro Techniques
- Mutation
- Xeroderma Pigmentosum