Article
Chrysotile fiber is a strong mutagen in mammalian cells.
Cancer research - 15 Nov 1992
Hei T K, Piao C Q, He Z Y, Vannais D, Waldren C A
Abstract excerpt
Although chrysotile asbestos is a proven human carcinogen, several studies have concluded that these fibers are not mutagenic to cultured mammalian cells. We show here, on the other hand, that when tested using the AL cell system that detects both intragenic and multilocus mutations, chrysotile i...
Topics
- Animals
- Antigens, Surface
- Asbestos
- Asbestos, Serpentine
- Blotting, Southern
- CHO Cells
- Cell Survival
- Cells, Cultured
- Chromosomes, Human, Pair 11
- Cricetinae
- Fibroblasts
- Humans
- Hybrid Cells
- Hypoxanthine Phosphoribosyltransferase
- Mutagenesis
- Mutagens
- Phenotype