DNA damage and mutations induced by arachidonic acid peroxidation.

doi:10.1021/bi035555w

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Article

DNA damage and mutations induced by arachidonic acid peroxidation.

Biochemistry - 30 Dec 2003

Lim Punnajit, Sadre-Bazzaz Kianoush, Shurter Jesse, Sarasin Alain, Termini John

Abstract excerpt

Endogenous cellular oxidation of omega6-polyunsaturated fatty acids (PUFAs) has long been recognized as a contributing factor in the development of various cancers. The accrual of DNA damage as a result of reaction with free radical and electrophilic aldehyde products of lipid peroxidation is believed to be involved; however, the genotoxic and mutation-inducing potential of specific membrane PUFAs remains poorly...

Topics

Arachidonic Acid
Base Sequence
Cell Line
Chromosome Breakage
DNA
DNA Damage
DNA Mutational Analysis
DNA Repair
Electrophoresis, Agar Gel
Free Radicals
Genetic Complementation Test
Humans
Lipid Peroxidation
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Oxidation-Reduction
Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 14690412
DOI: 10.1021/bi035555w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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