Article
Primary resistance to integrase strand-transfer inhibitors in Europe.
The Journal of antimicrobial chemotherapy - 1 Oct 2015
Casadellà M, van Ham P M, Noguera-Julian M, van Kessel A, Pou C, Hofstra L M, Santos J R, Garcia F, Struck D, Alexiev I, Bakken Kran A M, Hoepelman A I, Kostrikis L G, Somogyi S, Liitsola K, Linka M, Nielsen C, Otelea D, Paraskevis D, Poljak M, Puchhammer-Stöckl E, Staneková D, Stanojevic M, Van Laethem K, Zidovec Lepej S, Clotet B, Boucher C A B, Paredes R, Wensing A M J
Abstract excerpt
OBJECTIVES: The objective of this study was to define the natural genotypic variation of the HIV-1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer inhibitor (InSTI) resistance. METHODS: This was a multicentre, cross-sectional study within the European SPREAD HIV resistance surveillance programme. A representative set of 300 samples was selected from 1950 naive...
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