Article
Matrix nonenzymatic glycosylation leads to altered cellular phenotype and intracellular tyrosine phosphorylation.
The Journal of biological chemistry - 17 Feb 1995
Hasegawa G, Hunter A J, Charonis A S
Abstract excerpt
The effect of matrix nonenzymatic glycosylation on signal transduction and the cellular phenotype was examined. Human microvascular endothelial cells were plated on control or glycated basement membrane-like matrix. Cells exhibited a decrease in their ability to adhere and spread on modified matr...
Topics
- Animals
- Basement Membrane
- Blotting, Western
- Cell Adhesion
- Cell Adhesion Molecules
- Cells, Cultured
- Cytoskeletal Proteins
- Cytoskeleton
- Electrophoresis, Polyacrylamide Gel
- Endothelium, Vascular
- Extracellular Matrix
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Glycosylation
- Humans
- Kinetics
- Mice
- Mice, Inbred BALB C