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Article

Cytokine sensitivity and N-glycan processing mutations.

Methods in enzymology - 1 Jan 2006

Partridge Emily A, Cheung Pam, Dennis James W

Abstract excerpt

The EGF and TGF-beta families of cytokines are critical regulators of cell proliferation, morphogenesis, and tissue repair. The signaling pathways downstream of EGF and TGF-beta receptors also contribute to cancer growth and metastasis. Cytokine receptors are glycoproteins, and we have recently shown that GlcNAc-branching of N-glycans enhances their cell surface residency and contributes to the growth autonomy of...

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Identifiers

PMID: 17132493
DOI: 10.1016/S0076-6879(06)17001-9

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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