Article

<i>In silico</i> -based screening for natural product’s structural analogs as new drugs candidate against leishmaniasis

2022-07-23

Abstract excerpt

Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Hence, this study aims to in silico screen for natural product’s structural analogs as new drugs candidate against leishmaniasis. We applied in silico analysis, such as virtual screening, molecular docking, molecula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b1746df-d0d5-5f55-824d-11a23c5c3c88
DOI: 10.1101/2022.07.22.501189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In silico</i> -based screening for natural product’s structural analogs as new drugs candidate against leishmaniasisDOI 10.1101/2022.07.22.501189Read

Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania sppSemantic proximity Read

Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through <i>In Silico</i> Analysis And <i>In Vitro</i> EfficacySemantic proximity Read

QSAR, Docking and Molecular Dynamic Simulation studies of Leishmanial Inhibitors using bioinformatics approachSemantic proximity Read

Computational Analysis of Luteolin, Apigenin and Their Derivatives from Allophylus africanus as Potential Inhibitors of Plasmepsin II a Malaria TargetSemantic proximity Read

Theoretical activity prediction, structure-based design, molecular docking and pharmacokinetic studies of some maleimides against Leishmania donovani for the treatment of leishmaniasisSemantic proximity Read

Targeting with Structural Analogs of Natural Products the Purine Salvage Pathway in Leishmania (Leishmania) infantum by Computer-Aided Drug-Design ApproachesSemantic proximity Read

Identification of potent natural compounds in targeting Leishmania major CYP51 and GP63 proteins using a high-throughput computationally enhanced screeningSemantic proximity Read

Potential therapeutic targets and the role of technology in developing novel antileishmanial drugs.Semantic proximity Read

An extensive computational approach to inhibit MSP-1 of <i>P.vivax</i> elucidates further horizon in the establishment next generation therapeutics against malariaSemantic proximity Read

Nature Potential for COVID-19: Targeting SARS-CoV-2 Mpro Inhibitor with Bioactive CompoundSemantic proximity Read

In silico and in vitro comparative activity of novel experimental derivatives against Leishmania major and Leishmania infantum promastigotesSemantic proximity Read

In Silico Drug Discovery: Unveiling Potential Targets in Plasmodium falciparum through Molecular Docking AnalysisSemantic proximity Read