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Article

The Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles

21 Mar 2013

Abstract excerpt

The Type Three Secretion System (T3SS), or injectisome, is a macromolecular infection machinery present in many pathogenic Gram-negative bacteria. It consists of a basal body, anchored in both bacterial membranes, and a hollow needle through which effector proteins are delivered into the target host cell. Two different architectures of the T3SS needle have been previously proposed. First, an atomic model of the...

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PMID: 23555258
DOI: 10.1371/journal.ppat.1003245

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