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Article

Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype.

European journal of immunology - 1 Mar 2020

Povoleri Giovanni A M, Lalnunhlimi Sylvine, Steel Kathryn J A, Agrawal Shweta, O'Byrne Aoife M, Ridley Michael, Kordasti Shahram, Frederiksen Klaus S, Roberts Ceri A, Taams Leonie S

Abstract excerpt

TNF-blockade has shown clear therapeutic value in rheumatoid arthritis and other immune-mediated inflammatory diseases, however its mechanism of action is not fully elucidated. We investigated the effects of TNF-blockade on CD4+ T cell activation, maturation, and proliferation, and assessed whether TNF-inhibitors confer regulatory potential to CD4+ T cells. CyTOF and flow cytometry analysis revealed that in vitro...

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Identifiers

PMID: 31722123
DOI: 10.1002/eji.201948190
PMCID: PMC7079027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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