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Article

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.

Blood - 1 Jul 2006

Valencia Xavier, Stephens Geoffrey, Goldbach-Mansky Raphaela, Wilson Mildred, Shevach Ethan M, Lipsky Peter E

Abstract excerpt

CD4+CD25+ T-regulatory cells (Tregs) play an essential role in maintaining immunologic homeostasis and preventing autoimmunity. However, little is known about the exogenous factors that regulate their differentiation and function. Here, we report that TNF inhibits the suppressive function of both naturally occurring CD4+CD25+ Tregs and TGFbeta1-induced CD4+CD25+ T-regulatory cells. The mechanism of this...

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Source

Open in PubMed Open full text

Identifiers

PMID: 16537805
DOI: 10.1182/blood-2005-11-4567
PMCID: PMC1895836

Genes

TNF
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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