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Article

Inhibition of activation induced CD154 on CD4+ CD25- cells: a valid surrogate for human Treg suppressor function.

Immunology and cell biology - 1 Sept 2012

Hill Danika, Eastaff-Leung Nicola, Bresatz-Atkins Suzanne, Warner Noel, Ruitenberg Joyce, Krumbiegel Doreen, Pederson Steve, McInnes Natasha, Brown Cheryl Y, Sadlon Timothy, Barry Simon C

Abstract excerpt

Natural Regulatory T cells (Tregs) are defined by stable expression of the cell surface proteins CD4 and CD25, low surface expression of CD127 and expression of the transcription factor FOXP3. The contribution of Treg to the prevention of autoimmunity and the maintenance of immune homoestasis is the subject of ongoing interest, as alterations in Treg numbers and function are implicated in a wide range of...

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Identifiers

PMID: 22689014
DOI: 10.1038/icb.2012.18

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FOXP3

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