Article
Molecular determinants of Ebola virus virulence in mice.
PLoS pathogens - 1 Jul 2006
Ebihara Hideki, Takada Ayato, Kobasa Darwyn, Jones Steven, Neumann Gabriele, Theriault Steven, Bray Mike, Feldmann Heinz, Kawaoka Yoshihiro
Abstract excerpt
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to cause lethal infection in these animals. To understand the pathogenesis underlying the extreme virulence of Ebola...
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