Article

Engineering Treg-mediated immune tolerance via <i>foxp3a</i> overexpression to evade allograft transplantation barriers in zebrafish

2025-10-16

Abstract excerpt

In mammals, regulatory T cells (Treg) cells have been utilized to enhance tolerance in organ transplantation. Although transplanting germline stem cells (GSCs) or gonadal primordia into immunodeficient zebrafish have shown to be an important technique which can bypass the juvenile phase and expedite gamete generation, it remains challenging to raise the immunodeficient fish. Here, we achieved in vivo induction of...

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Literature Corpus work: b6dd3c12-44b2-594a-8e34-8189f2077af6
DOI: 10.1101/2025.10.15.682525

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