Article

Comprehensively Testing the Function of Missense Variation in the <i>STK11</i> Tumour Suppressor

2025-07-18

Abstract excerpt

The tumor suppressor gene STK11 encoding Serine/Threonine Kinase 11 (STK11) is associated with Peutz-Jeghers Syndrome (PJS), a heritable gastrointestinal disease that increases lifetime cancer risk, and with somatic variation that contributes to ∼30% of lung and 20% of cervical cancers. Although identifying pathogenic variants is clinically actionable, over 94% of STK11 missense variants that have been observed...

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Literature Corpus work: 68af2102-91f0-5278-bfe6-81556c8c8c7b
DOI: 10.1101/2025.07.14.664734

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