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Article

An in-silico study to determine susceptibility to cancer by evaluating the coding and non-coding non-synonymous single nucleotide variants in the SOCS3 gene.

Journal of biomolecular structure & dynamics - 1 Oct 2024

Fatemeh Sadri, Mahboobeh Zarei, Khadijeh Ahmadi, Amirhossein Mohajeri Khorasani, Pegah Mousavi

Abstract excerpt

Single Nucleotide Variant (SNVs) affect gene expression as well as protein structure and activity, leading to reduced signaling capabilities and ultimately, increasing cancer risk. SOCS3 (suppressor of cytokine signaling 3), a critical tumor suppressor providing a substantial part in the feedback loop of the JAK/STAT pathway, is abnormally suppressed in various cancer. This study aims to screen non-coding and...

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PMID: 37753777
DOI: 10.1080/07391102.2023.2256408

Genes

SOCS3

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