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Article

Tissue-adjusted pathway analysis of cancer (TPAC)

2022-03-19

Abstract excerpt

We describe a novel single sample pathway analysis method for cancer transcriptomics data named tissue-adjusted pathway analysis of cancer (TPAC). The TPAC method leverages information about the normal tissue-specificity of human genes to compute a robust multivariate distance score that quantifies pathway dysregulation in each profiled tumor. Because the null distribution of the TPAC scores has an accurate gamma...

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Literature Corpus work
5e1dc505-6686-5676-a973-6a03dd13c069
DOI
10.1101/2022.03.17.484779
Open publication

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Tissue-adjusted pathway analysis of cancer (TPAC)DOI 10.1101/2022.03.17.484779
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