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Article

A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition.

American journal of physiology. Renal physiology - 1 Jan 2019

Ó hAinmhire Eoghainín, Wu Haojia, Muto Yoshiharu, Donnelly Erinn L, Machado Flavia G, Fan Lucy X, Chang-Panesso Monica, Humphreys Benjamin D

Abstract excerpt

Glioma-associated oncogene homolog-1 (Gli1)-positive resident mesenchymal stem cell-like cells are the predominant source of kidney myofibroblasts in fibrosis, but investigating Gli1-positive myofibroblast progenitor activation is hampered by the difficulty of isolating and propagating primary cultures of these cells. Using a genetic strategy with positive and negative selection, we isolated Kidney-Gli1 (KGli1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30303712
DOI: 10.1152/ajprenal.00460.2018
PMCID: PMC6383201

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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