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Article

Making sense of giant cell lesions of the jaws (GCLJ): lessons learned from next-generation sequencing.

The Journal of pathology - 1 Feb 2020

Gomes Carolina C, Diniz Marina G, Bastos Victor C, Bernardes Vanessa F, Gomez Ricardo S

Abstract excerpt

Next-generation sequencing has revealed mutations in several bone-related lesions and was recently used to uncover the genetic basis of giant cell lesions of the jaws (GCLJ). Consistent with their benign nature, GCLJ show a low tumor mutation burden. They also harbor somatic, heterozygous, mutually exclusive mutations in TRPV4, KRAS, or FGFR1. These signature mutations occur only in a subset of lesional cells,...

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Identifiers

PMID: 31705763
DOI: 10.1002/path.5365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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