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Article

Significant association between FGFR1 mutation frequency and age in central giant cell granuloma.

Pathology - 1 Apr 2023

Niada Stefania, Varazzani Andrea, Giannasi Chiara, Fusco Nicola, Armiraglio Elisabetta, Di Bernardo Andrea, Cherchi Alessandro, Baj Alessandro, Corradi Domenico, Tafuni Alessandro, Parafioriti Antonina, Ferrero Stefano, Bianchi Andrea Edoardo, Giannì Aldo Bruno, Poli Tito, Latif Farida, Brini Anna Teresa

Abstract excerpt

Central giant cell granulomas (CGCG) are rare intraosseous osteolytic lesions of uncertain aetiology. Despite the benign nature of this neoplasia, the lesions can rapidly grow and become large, painful, invasive, and destructive. The identification of molecular drivers could help in the selection of targeted therapies for specific cases. TRPV4, KRAS and FGFR1 mutations have been associated with these lesions but...

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PMID: 36428107
DOI: 10.1016/j.pathol.2022.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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