Central giant cell granulomas of the jaws stromal cells harbour mutations and have osteogenic differentiation capacity, in vivo and in vitro.

doi:10.1111/jop.13274

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Article

Central giant cell granulomas of the jaws stromal cells harbour mutations and have osteogenic differentiation capacity, in vivo and in vitro.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Feb 2022

Miguita Lucyene, de Souza Juliana Cristina, Bastos Victor Coutinho, Pereira Nubia Braga, de Freitas Raphaela Alvarenga Braga, Guimarães Leticia Martins, de Avelar Gleide Fernandes, Andrade Luciana Oliveira, Dutra Walderez Ornelas, Nunes Fábio Daumas, Castro Wagner Henriques, de Lacerda Julio Cesar Tanos, Reis Amanda Maria Sena, Bernardes Vanessa Fátima, Diniz Marina Gonçalves, Gomez Ricardo Santiago, Gomes Carolina Cavalieri

Abstract excerpt

BACKGROUND: Central giant cell granulomas (CGCG) of the jaws are osteolytic lesions that may behave aggressively and respond poorly to surgery. Microscopically, in addition to giant cells, there is a mononuclear cell population composed of macrophage/monocytic cells and spindle-shaped cells of mesenchymal origin. Seventy two percent of these tumours harbour mutually exclusive TRPV4, KRAS and FGFR1 mutations. We...

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PMID: 35048460
DOI: 10.1111/jop.13274

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