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Article

Tumor genetic alterations and features of the immune microenvironment drive myelodysplastic syndrome escape and progression.

Cancer immunology, immunotherapy : CII - 1 Dec 2019

Montes Paola, Bernal Mónica, Campo Laura N, González-Ramírez Amanda Rocío, Jiménez Pilar, Garrido Pilar, Jurado Manuel, Garrido Federico, Ruiz-Cabello Francisco, Hernández Francisca

Abstract excerpt

The transformation and progression of myelodysplastic syndromes (MDS) to secondary acute myeloid leukemia (sAML) involve genetic, epigenetic, and microenvironmental factors. Driver mutations have emerged as valuable markers for defining risk groups and as candidates for targeted treatment approaches in MDS. It is also evident that the risk of transformation to sAML is increased by evasion of adaptive immune...

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Identifiers

PMID: 31705171
DOI: 10.1007/s00262-019-02420-x
PMCID: PMC11028123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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