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Article

MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.

Oncogene - 1 Feb 2020

Sun Chaoyang, Li Xi, Guo Ensong, Li Na, Zhou Bo, Lu Hao, Huang Jia, Xia Meng, Shan Wanying, Wang Beibei, Li Kezhen, Weng Danhui, Xu Xiaoyan, Gao Qinglei, Wang Shixuan, Hu Junbo, Lu Yiling, Mills Gordon B, Chen Gang

Abstract excerpt

Ovarian cancer selective metastasizes to the omentum contributing to the poor prognosis associated with ovarian cancer. However, the mechanism underlining this propensity and therapeutic approaches to counter this process has not been fully elucidated. Here, we show that MCP-1 produced by omental adipocytes binding to its cognate receptor CCR-2 on ovarian cancer cells facilitates migration and omental metastasis...

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Share to Adipocytes
Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Peritoneal Neoplasms

Share to Proto-Oncogene Proteins c-akt

Share to Receptors, CCR2

Share to TOR Serine-Threonine Kinases

Share to Vascular Endothelial Growth Factor A

Source

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Identifiers

PMID: 31705064
DOI: 10.1038/s41388-019-1090-1
PMCID: PMC8290627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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