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Article

CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway.

Journal of molecular cell biology - 3 Aug 2023

He Xi, Wang Lieliang, Li Honghui, Liu Yaru, Tong Chang, Xie Caifeng, Yan Xiaohua, Luo Daya, Xiong Xiangyang

Abstract excerpt

Recent studies have demonstrated that cancer-associated adipocytes (CAAs) in the tumor microenvironment are involved in the malignant progression of breast cancer. However, the underlying mechanism of CAA formation and its effects on the development of breast cancer are still unknown. Here, we show that CSF2 is highly expressed in both CAAs and breast cancer cells. CSF2 promotes inflammatory phenotypic changes of...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37073091
DOI: 10.1093/jmcb/mjad025
PMCID: PMC10686244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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