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Article

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.

Neurobiology of aging - 1 Sept 2011

Vogt D L, Thomas D, Galvan V, Bredesen D E, Lamb B T, Pimplikar S W

Abstract excerpt

Alterations in the processing of the amyloid precursor protein (APP) lead to familial Alzheimer's disease (AD). AD patients exhibit increased seizure susceptibility and alterations in their EEGs, which suggests that APP and its metabolites may modulate neuronal networks. Here we demonstrate that transgenic mice overexpressing APP intracellular domain (AICD) and its binding partner Fe65 exhibit abnormal spiking...

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Source

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Identifiers

PMID: 19828212
DOI: 10.1016/j.neurobiolaging.2009.09.002
PMCID: PMC2889215

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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