Article
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
Nature communications - 12 Apr 2016
Orr Nathan, Arnaout Rima, Gula Lorne J, Spears Danna A, Leong-Sit Peter, Li Qiuju, Tarhuni Wadea, Reischauer Sven, Chauhan Vijay S, Borkovich Matthew, Uppal Shaheen, Adler Arnon, Coughlin Shaun R, Stainier Didier Y R, Gollob Michael H
Abstract excerpt
Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly understood, which contributes to the current lack of highly effective therapies. Recognizing mechanistic subtypes of AF may guide an individualized approach to patient management. Here, we describe a family with a previously unreported...
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