NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.

doi:10.1136/annrheumdis-2019-215820

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Article

NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Feb 2020

Linge Petrus, Arve Sabine, Olsson Lina M, Leonard Dag, Sjöwall Christopher, Frodlund Martina, Gunnarsson Iva, Svenungsson Elisabet, Tydén Helena, Jönsen Andreas, Kahn Robin, Johansson Åsa, Rönnblom Lars, Holmdahl Rikard, Bengtsson Anders

Abstract excerpt

OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). This study aimed at characterising NCF1-339 effects on neutrophil extracellular trap (NET) formation, type I interferon activity and...

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PMID: 31704719
DOI: 10.1136/annrheumdis-2019-215820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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