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Article

Correlation of Secretory Activity of Neutrophils With Genotype in Patients With Familial Mediterranean Fever.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Dec 2016

Gohar Faekah, Orak Banu, Kallinich Tilmann, Jeske Marion, Lieber Mareike, von Bernuth Horst, Giese Arnd, Weissbarth-Riedel Elisabeth, Haas Johannes-Peter, Dressler Frank, Holzinger Dirk, Lohse Peter, Neudorf Ulrich, Lainka Elke, Hinze Claas, Masjosthusmann Katja, Kessel Christoph, Weinhage Toni, Foell Dirk, Wittkowski Helmut

Abstract excerpt

OBJECTIVE: Familial Mediterranean fever (FMF) is an autoinflammatory disorder caused by pyrin-encoding MEFV mutations. Patients present with recurrent but self-limiting episodes of acute inflammation and often have persistent subclinical inflammation. The pathophysiology is only partially understood, but neutrophil overactivation is a hallmark of the disease. S100A12 is a neutrophil-derived proinflammatory danger...

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Identifiers

PMID: 27333294
DOI: 10.1002/art.39784

Genes

MEFV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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