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Article

Neutrophil Extracellular Traps-DNase Balance and Autoimmunity.

Cells - 5 Oct 2021

Angeletti Andrea, Volpi Stefano, Bruschi Maurizio, Lugani Francesca, Vaglio Augusto, Prunotto Marco, Gattorno Marco, Schena Francesca, Verrina Enrico, Ravelli Angelo, Ghiggeri Gian Marco

Abstract excerpt

Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating bacteria and viruses. The accumulation of NETs in the circulation correlates with the formation of anti-double-stranded (ds) DNA antibodies and is considered a causative factor for systemic lupus erythematosus (SLE). The digestion of DNA by DNase1 and DNases1L3 is the rate- limiting factor for NET accumulation....

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Identifiers

PMID: 34685647
DOI: 10.3390/cells10102667
PMCID: PMC8534732

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