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Article

Association between HLA-B44:03-HLA-C07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand.

The British journal of ophthalmology - 1 Sept 2018

Jongkhajornpong Passara, Lekhanont Kaevalin, Pisuchpen Phattrawan, Chantaren Patchima, Puangsricharern Vilavun, Prabhasawat Pinnita, Suphapeetiporn Kanya, Kinoshita Shigeru, Ueta Mayumi

Abstract excerpt

BACKGROUND: Polymorphisms in human leucocyte antigen (HLA) class I genes have been found to be associated with cold medicine (CM)-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications (SOC). Because ethnic differences in genetic predisposition to SJS/TEN among different populations have been proposed, we focused on Thai patients and investigated the...

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PMID: 29706602
DOI: 10.1136/bjophthalmol-2017-311823

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