Article
MicroRNA-17-92 cluster regulates osteoblast proliferation and differentiation.
Endocrine - 1 Mar 2014
Zhou Mingliang, Ma Junrong, Chen Shiju, Chen Xiang, Yu Xijie
Abstract excerpt
MicroRNAs (miRNAs) have been identified to play important functions during osteoblast proliferation, differentiation, and apoptosis. The miR-17~92 cluster is highly conserved in all vertebrates. Loss-of-function of the miR-17-92 cluster results in smaller embryos and immediate postnatal death of all animals. Germline hemizygous deletions of MIR17HG are accounted for microcephaly, short stature, and digital...
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