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Article

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.

Blood - 19 Jun 2014

Duek Adrian, Lundberg Pontus, Shimizu Takafumi, Grisouard Jean, Karow Axel, Kubovcakova Lucia, Hao-Shen Hui, Dirnhofer Stephan, Skoda Radek C

Abstract excerpt

The interferon-γ (IFNγ)/signal transducer and activator of transcription 1 (Stat1) pathway shows higher activity in patients with essential thrombocythemia (ET) than in polycythemia vera (PV) and was proposed to be promoting the ET phenotype. We explored the phenotypic consequences of Stat1 deficiency on the effects of Janus kinase 2 (JAK2)-V617F in vivo by crossing mice expressing JAK2-V617F with Stat1 knockout...

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Source

Identifiers

PMID: 24820309
DOI: 10.1182/blood-2013-07-514208

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.PMID 24820309Read ↗

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Role of JAK-STAT Signaling in the Pathogenesis of Myeloproliferative DisordersSemantic proximity Read ↗

STAT1 promotes megakaryopoiesis downstream of GATA-1 in miceSemantic proximity Read ↗

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.Semantic proximity Read ↗

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemiaSemantic proximity Read ↗

JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionalitySemantic proximity Read ↗

The JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspectiveSemantic proximity Read ↗

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