Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.

Blood - 19 Jun 2014

Duek Adrian, Lundberg Pontus, Shimizu Takafumi, Grisouard Jean, Karow Axel, Kubovcakova Lucia, Hao-Shen Hui, Dirnhofer Stephan, Skoda Radek C

Abstract excerpt

The interferon-γ (IFNγ)/signal transducer and activator of transcription 1 (Stat1) pathway shows higher activity in patients with essential thrombocythemia (ET) than in polycythemia vera (PV) and was proposed to be promoting the ET phenotype. We explored the phenotypic consequences of Stat1 defic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Neoplasms
Share to Bone Marrow Transplantation
Share to Erythropoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Polycythemia Vera

Share to STAT1 Transcription Factor

Share to Thrombocythemia, Essential

Share to Thrombopoiesis

Source

Identifiers

PMID: 24820309
DOI: 10.1182/blood-2013-07-514208

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24820309-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.PMID 24820309Read ↗

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPNSemantic proximity Read ↗

Role of JAK-STAT Signaling in the Pathogenesis of Myeloproliferative DisordersSemantic proximity Read ↗

STAT1 promotes megakaryopoiesis downstream of GATA-1 in miceSemantic proximity Read ↗

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.Semantic proximity Read ↗

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemiaSemantic proximity Read ↗

JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionalitySemantic proximity Read ↗

The JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspectiveSemantic proximity Read ↗

A role for JAK2 mutations in myeloproliferative diseases.Semantic proximity Read ↗

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells.Semantic proximity Read ↗

Mutated JAK2 signal transduction in human induced pluripotent stem cell (iPSC)-derived megakaryocytes.Semantic proximity Read ↗

Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F.Semantic proximity Read ↗

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.