Article
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F.
Leukemia - 1 Jan 2008
Shide K, Shimoda H K, Kumano T, Karube K, Kameda T, Takenaka K, Oku S, Abe H, Katayose K S, Kubuki Y, Kusumoto K, Hasuike S, Tahara Y, Nagata K, Matsuda T, Ohshima K, Harada M, Shimoda K
Abstract excerpt
An acquired JAK2 V617F mutation is found in most patients with polycythemia vera (PV), and about half of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF). Mice transplanted with bone marrow cells in which JAK2 V617F was retrovirally expressed developed PV-like features, but not ET or PMF. To address the contribution of this mutation to the pathogenesis of these three MPDs, we generated...
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