Article
MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance.
Blood - 19 Nov 2015
Kwok Brian, Hall Jeff M, Witte John S, Xu Yin, Reddy Prashanti, Lin Keming, Flamholz Rachel, Dabbas Bashar, Yung Aine, Al-Hafidh Jenan, Balmert Emily, Vaupel Christine, El Hader Carlos, McGinniss Matthew J, Nahas Shareef A, Kines Julie, Bejar Rafael
Abstract excerpt
Establishing a diagnosis in patients suspected of having a myelodysplastic syndrome (MDS) can be challenging and could be informed by the identification of somatic mutations. We performed a prospective study to examine the frequency and types of mutations encountered in 144 patients with unexplained cytopenias. Based on bone marrow findings, 17% were diagnosed with MDS, 15% with idiopathic cytopenias of...
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