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Article

A long-range RNA–RNA interaction between the 5′ and 3′ ends of the HCV genome

15 Jul 2009

Abstract excerpt

The RNA genome of the hepatitis C virus (HCV) contains multiple conserved structural cis domains that direct protein synthesis, replication, and infectivity. The untranslatable regions (UTRs) play essential roles in the HCV cycle. Uncapped viral RNAs are translated via an internal ribosome entry site (IRES) located at the 5' UTR, which acts as a scaffold for recruiting multiple protein factors. Replication of the...

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PMID: 19605533
DOI: 10.1261/rna.1680809

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