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Knockdown GREM1 suppresses cell growth, angiogenesis, and epithelial‐mesenchymal transition in colon cancer

13 Nov 2018

Abstract excerpt

Gremlin 1 (GREM1), as a bone morphogenetic protein (BMP) antagonist and vascular endothelial growth factor receptor-2 (VEGFR2) novel agonist, has been confirmed as overexpressed in colorectal cancer (CRC) tissues but its role in carcinogenesis remains unclear. Here we reported that the GREM1 expression in mesenchymal-like colon cancer cells (SW620 and SW480) was significantly higher than that of epithelial-like...

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PMID: 30426548
DOI: 10.1002/jcb.27842

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