Article
Accumulation and Intranuclear Distribution of Unintegrated Human Immunodeficiency Virus Type 1 DNA
15 Aug 2001
Abstract excerpt
The RNA genome of human immunodeficiency virus type 1 (HIV-1) is converted into DNA after infection in order to integrate into the host cell DNA. However, a large number of these reverse-transcribed genomes remain unintegrated in the nucleus of infected cells. Currently, there are no data available about the intranuclear distribution pattern of unintegrated HIV-1 DNA in relation to nuclear structures as observed...