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Article

Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record.

BMC genomics - 4 Nov 2019

Hughey Jacob J, Rhoades Seth D, Fu Darwin Y, Bastarache Lisa, Denny Joshua C, Chen Qingxia

Abstract excerpt

BACKGROUND: The growth of DNA biobanks linked to data from electronic health records (EHRs) has enabled the discovery of numerous associations between genomic variants and clinical phenotypes. Nonetheless, although clinical data are generally longitudinal, standard approaches for detecting genotype-phenotype associations in such linked data, notably logistic regression, do not naturally account for variation in...

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PMID: 31684865
DOI: 10.1186/s12864-019-6192-1
PMCID: PMC6829851

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