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Exploring Plasmodium falciparum Var Gene Expression to Assess Host Selection Pressure on Parasites During Infancy

9 Oct 2019

Abstract excerpt

In sub-Saharan Africa, children below five years bear the greatest burden of severe malaria because they lack naturally acquired immunity that develops following repeated exposure to infection by Plasmodium falciparum. Antibodies to the surface of P. falciparum infected erythrocytes (IEs) play an important role in this immunity. In children under the age of six months, relative protection from severe malaria is...

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PMID: 31681266
DOI: 10.3389/fimmu.2019.02328

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