Article
The history of mutational pressure changes during the evolution of adeno-associated viruses: A message to gene therapy and DNA-vaccine vectors designers.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2020
Khrustalev Vladislav Victorovich, Khrustaleva Tatyana Aleksandrovna, Stojarov Aleksander Nikolaevich, Sharma Nitin, Bhaskar Bhaskar, Giri Rajanish
Abstract excerpt
The use of virus-associated vectors for gene therapy and vaccination have emerged as safe and effective delivery system. Like all other genetic materials, these vehicles are also prone to spontaneous mutations. To understand what types of nucleotide mutations are expected in the vector, one needs to know distinct characteristics of mutational process in the corresponding virus. In this study we analyzed...
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